Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PARG | Q86W56 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL4153174 | 1.00 | TDP1 (0.56) | TDP1PARGBRAFALDH1A1TAS2R14 | |
| Propionic Acid SCHEMBL4153577 | 0.96 | PARG (0.57) | TDP1PARGBRAFALDH1A1TAS2R14 | |
| Propionic Acid SCHEMBL4168582 | 0.93 | PARG (0.51) | TDP1PARGBRAFALDH1A1TAS2R14 | |
| SCHEMBL4713589 | 0.92 | TDP1 (0.61) | TDP1PARGBRAFALDH1A1TAS2R14 | |
| Butyric Acid SCHEMBL4161248 | 0.90 | PARG (0.55) | TDP1PARGBRAFALDH1A1KMT2A | |
| Propionic Acid SCHEMBL4163336 | 0.89 | PARG (0.47) | TDP1PARGBRAFALDH1A1TAS2R14 | |
| Butyric Acid SCHEMBL4164937 | 0.87 | PARG (0.49) | TDP1PARGBRAFALDH1A1TAS2R14 | |
| Propionic Acid SCHEMBL4160991 | 0.85 | BRD4 (0.39) | TDP1PARGALDH1A1KMT2AMEN1 | |
| Valeric Acid SCHEMBL4165049 | 0.85 | PARG (0.47) | TDP1PARGBRAFALDH1A1KMT2A | |
| Propionic Acid SCHEMBL4160658 | 0.85 | TAS2R14 (0.49) | PARGBRAFALDH1A1TAS2R14PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | claimed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | claimed |
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | TDP1 1098/4885PARG 3507/4885BRAF 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.