SCHEMBL4157728

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4140548	0.82	PIM1 (0.51)	PIM1KDRMAPK8
	SCHEMBL5034342	0.80	MAPK1 (0.51)	CDK2MAPK1
	SCHEMBL2855850	0.79	MAP2K4 (0.59)	CA12MAPKAPK2CDK4CCNA2CCND1
	SCHEMBL4144044	0.79	MAPKAPK2 (0.48)	GABRPGABRDGABRA1GABRB1GABRG2
	SCHEMBL4151243	0.79	CA12 (0.47)	CA12MAPKAPK2CDK4CCNA2CCND1
	SCHEMBL4153491	0.78	CA12 (0.49)	KMT2ACA12MAPKAPK2CDK4CCNA2
	SCHEMBL5032344	0.78	CNR1 (0.48)	GABRA1GABRG2GABRB3GABRA5GABRA3
	SCHEMBL5032424	0.78	RAB9A (0.53)	KMT2AMAPK1MAPK8
	SCHEMBL4150719	0.77	CA12 (0.48)	CA12MAPKAPK2CDK4CCNA2CCND1
	SCHEMBL4146053	0.76	PIM1 (0.50)	GABRPGABRDGABRA1GABRB1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.