Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL4158106 | 0.91 | BRD4 (0.60) | BRD4HTR6PDE3A | |
| Propionic Acid SCHEMBL4163285 | 0.89 | PKM (0.54) | BRD4LMNAGAAPKMPDE3A | |
| Propionic Acid SCHEMBL4155591 | 0.87 | BRD4 (0.50) | BRD4KMT2AHTR6ALDH1A1MEN1 | |
| Propionic Acid SCHEMBL4162506 | 0.86 | BRD4 (0.50) | BRD4ALDH1A1LMNAHIF1APKM | |
| Propionic Acid SCHEMBL4164250 | 0.86 | BRD4 (0.62) | BRD4KMT2AHTR6ALDH1A1MEN1 | |
| Propionic Acid SCHEMBL4169897 | 0.86 | BRD4 (0.59) | BRD4HTR6HIF1AGAAPKM | |
| Propionic Acid SCHEMBL4155599 | 0.86 | BRD4 (0.49) | BRD4KMT2AHTR6MEN1GAA | |
| Propionic Acid SCHEMBL4159957 | 0.86 | BRD4 (0.49) | BRD4KMT2AHTR6MEN1HIF1A | |
| Propionic Acid SCHEMBL4157596 | 0.86 | BRD4 (0.52) | BRD4ALDH1A1LMNASMN1; SMN2PKM | |
| Propionic Acid SCHEMBL4157723 | 0.85 | BRD4 (0.62) | BRD4KMT2AHTR6ALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | claimed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | claimed |
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | BRD4 545/4885KMT2A 1882/4885HTR6 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.