Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 9/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 8/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 3/20 | 0.34 |
| ▸ | PRKCH | P24723 | 3/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158665 | 0.91 | TGFBR1 (0.41) | TGFBR1CYP3A4CYP2C8PRKCQPRKCD | |
| SCHEMBL3672671 | 0.87 | TGFBR1 (0.39) | TGFBR1CYP3A4CYP2C8PRKCQPRKCD | |
| SCHEMBL4150333 | 0.87 | TGFBR1 (0.39) | TGFBR1CYP3A4CYP2C8NOS3NOS1 | |
| SCHEMBL4164617 | 0.82 | TGFBR1 (0.45) | TGFBR1CYP3A4CYP2C8PRKCQPRKCD | |
| SCHEMBL4155580 | 0.81 | PRKCQ (0.47) | TGFBR1CYP3A4CYP2C8PRKCQPRKCD | |
| SCHEMBL4149228 | 0.81 | CYP3A4 (0.46) | TGFBR1CYP3A4CYP2C8FLT3JAK2 | |
| SCHEMBL4165292 | 0.75 | TGFBR1 (0.47) | TGFBR1CYP3A4CYP2C8JAK1TGFBR2 | |
| SCHEMBL4151363 | 0.74 | TGFBR1 (0.53) | TGFBR1CYP3A4CYP2C8TGFBR2 | |
| SCHEMBL4153898 | 0.74 | TGFBR1 (0.53) | TGFBR1CYP3A4CYP2C8TGFBR2 | |
| SCHEMBL4157242 | 0.74 | TGFBR1 (0.50) | TGFBR1CYP3A4CYP2C8JAK1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | claimed |
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | disclosed |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | ALK, ACVR1, PTPN4 | TGFBR1 128/4885CYP3A4 111/4885CYP2C8 1297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.