Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.38 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.38 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3803691 | 0.89 | TGFBR1 (0.43) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B | |
| SCHEMBL4150483 | 0.88 | TGFBR1 (0.49) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B | |
| SCHEMBL4155020 | 0.83 | TGFBR1 (0.46) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B | |
| SCHEMBL4150426 | 0.83 | TGFBR1 (0.44) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B | |
| SCHEMBL3803436 | 0.82 | TGFBR1 (0.48) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B | |
| SCHEMBL4158344 | 0.82 | TGFBR1 (0.48) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B | |
| SCHEMBL3805478 | 0.82 | TGFBR1 (0.48) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B | |
| SCHEMBL4156754 | 0.82 | TGFBR1 (0.48) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B | |
| SCHEMBL4155037 | 0.81 | TGFBR1 (0.43) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B | |
| SCHEMBL4153879 | 0.81 | TGFBR1 (0.47) | TGFBR1CYP3A4CYP2C8PIP4K2APIP4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | claimed |
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | disclosed |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | disclosed |
| US-20090088438-A1 | NEW TYROSINE DERIVATIVES AS PPARy MODULATORS | LABORATORIOS SALVAT, S.A. (ES) | 2009-04-02 | — | — | US | disclosed |
| US-7423172-B2 | Tyrosine derivatives as PPAR-γ-modulators | LABORATORIOS SALVAT, S.A. (ES) | 2008-09-09 | — | — | US | disclosed |
| US-20070276043-A1 | Tyrosine Derivatives As Ppar-Gamma-Modulators | LABORATORIES SALVAT, S.A. (ES) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088438-A1 | NEW TYROSINE DERIVATIVES AS PPARy MODULATORS | PPARG, PPARD, TYRO3 | TGFBR1 993/4885CYP3A4 1146/4885CYP2C8 1062/4885 |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | ALK, ACVR1, PTPN4 | TGFBR1 128/4885CYP3A4 111/4885CYP2C8 1297/4885 |
| US-20070276043-A1 | Tyrosine Derivatives As Ppar-Gamma-Modulators | PPARG, PPARD, PPARA | TGFBR1 794/4885CYP3A4 873/4885CYP2C8 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.