Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | RAB9A | P51151 | 7/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | GCG | P01275 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595223 | 0.81 | NPC1 (0.55) | ESR2NPC1RAB9AFLT3POLB | |
| SCHEMBL28539532 | 0.77 | ESR2 (0.46) | ESR2NPC1RAB9AGCGLMNA | |
| SCHEMBL28967464 | 0.77 | MEN1 (0.49) | ESR2NPC1RAB9APOLBGCG | |
| SCHEMBL11901390 | 0.77 | ESR2 (0.62) | ESR2NPC1RAB9AGCGMEN1 | |
| SCHEMBL28553007 | 0.77 | ESR2 (0.66) | ESR2NPC1RAB9APOLBGCG | |
| SCHEMBL14036890 | 0.76 | ESR2 (0.47) | ESR2NPC1RAB9AFLT3POLB | |
| SCHEMBL2264530 | 0.76 | ESR2 (0.46) | ESR2NOTUMMAPT | |
| SCHEMBL28539726 | 0.74 | NPC1 (0.52) | ESR2NPC1RAB9AGCGMEN1 | |
| SCHEMBL2264359 | 0.74 | ESR2 (0.43) | ESR2NPC1RAB9APOLBGCG | |
| SCHEMBL16596068 | 0.74 | ESR2 (0.47) | ESR2NPC1RAB9APOLBGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012134-A1 | Arylsulfonyl Benzofused Heterocycles as 5-Ht2a Antagonists | CURTIS NEIL ROY | 2009-01-08 | — | — | US | disclosed |
| EP-1866300-A1 | ARYLSULFONYL BENZOFUSED HETEROCYCLES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006100519-A1 | ARYLSULFONYL BENZOFUSED HETEROCYCLES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012134-A1 | Arylsulfonyl Benzofused Heterocycles as 5-Ht2a Antagonists | HTR2A, HTR2C, HTR2B | ESR2 714/4885NPC1 2376/4885RAB9A 2044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.