Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.69 |
| ▸ | CDK8 | P49336 | 4/20 | 0.69 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.69 |
| ▸ | GSK3B | P49841 | 1/20 | 0.67 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.56 |
| ▸ | FER | P16591 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4164915 | 0.98 | AXL (0.67) | AXLCDK8TNIKGSK3BPLK4 | |
| SCHEMBL8941685 | 0.81 | AXL (1.00) | AXLCDK8TNIKPLK4AURKA | |
| SCHEMBL8321012 | 0.80 | MAPK8 (0.63) | AXLCDK8TNIKGSK3BMAPK8 | |
| SCHEMBL1800807 | 0.80 | AXL (0.73) | AXLCDK8TNIKGSK3BSGK1 | |
| SCHEMBL7112526 | 0.80 | GSK3B (1.00) | AXLCDK8TNIKGSK3BSGK1 | |
| SCHEMBL13854133 | 0.79 | CDK2 (0.63) | AXLCDK8TNIKGSK3BPLK4 | |
| Hydrochloric Acid SCHEMBL7113562 | 0.79 | GSK3B (0.97) | AXLCDK8TNIKGSK3BSGK1 | |
| SCHEMBL4166523 | 0.78 | CAMKK2 (0.63) | AXLCDK8PLK4DYRK1ACAMKK2 | |
| SCHEMBL8322551 | 0.78 | AXL (0.85) | AXLCDK8TNIKGSK3BPLK4 | |
| SCHEMBL1713684 | 0.76 | AXL (0.64) | AXLCDK8TNIKGSK3BIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | disclosed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | AXL 1542/4885CDK8 525/4885TNIK 212/4885 |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | SGK1, SGK2, SGK3 | AXL 1432/4885CDK8 639/4885TNIK 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.