Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206897 | 1.00 | CYP2D6 (0.33) | CYP2D6MEN1KMT2ALMNAL3MBTL3 | |
| SCHEMBL206436 | 0.98 | CYP2D6 (0.32) | CYP2D6MEN1KMT2ALMNAL3MBTL3 | |
| SCHEMBL204532 | 0.98 | CYP2D6 (0.32) | CYP2D6MEN1KMT2ALMNAL3MBTL3 | |
| SCHEMBL735235 | 0.95 | CYP2D6 (0.33) | CYP2D6MEN1KMT2ALMNAL3MBTL3 | |
| SCHEMBL736026 | 0.93 | CYP2D6 (0.32) | CYP2D6MEN1KMT2ALMNAL3MBTL3 | |
| SCHEMBL737923 | 0.93 | CYP2D6 (0.32) | CYP2D6MEN1KMT2ALMNAL3MBTL3 | |
| SCHEMBL739014 | 0.93 | CYP2D6 (0.32) | CYP2D6MEN1KMT2ALMNAL3MBTL3 | |
| SCHEMBL736908 | 0.92 | L3MBTL3 (0.32) | CYP2D6MEN1KMT2ALMNAL3MBTL3 | |
| SCHEMBL9469528 | 0.92 | — | — | |
| SCHEMBL737602 | 0.90 | L3MBTL3 (0.31) | L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
| US-20080221157-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGE (IT) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221157-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC4 | CYP2D6 3491/4885MEN1 4119/4885KMT2A 44/4885 |
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | CYP2D6 3094/4885MEN1 3953/4885KMT2A 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.