Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143243 | 0.90 | FYN (0.57) | FYNMKNK1MKNK2ROCK2ROCK1 | |
| SCHEMBL4190030 | 0.87 | FYN (0.60) | FYNMKNK1MKNK2ROCK2ROCK1 | |
| SCHEMBL4138960 | 0.86 | FYN (0.60) | FYNROCK2ROCK1HIF1ACYP11B2 | |
| SCHEMBL4148055 | 0.85 | FYN (0.57) | FYNROCK2ROCK1HIF1ACYP11B2 | |
| SCHEMBL4146617 | 0.84 | FYN (0.64) | FYNROCK2ROCK1HIF1ACYP11B2 | |
| SCHEMBL4191754 | 0.83 | FYN (0.57) | FYNMKNK1MKNK2ROCK2ROCK1 | |
| SCHEMBL4155317 | 0.83 | FYN (0.59) | FYNROCK2ROCK1MAP4K4HIF1A | |
| SCHEMBL4160677 | 0.82 | FYN (0.73) | FYNROCK2ROCK1HIF1ACYP11B2 | |
| SCHEMBL27502394 | 0.82 | HIF1A (0.63) | ROCK2ROCK1HIF1APPARGAURKA | |
| SCHEMBL4180476 | 0.81 | FYN (0.58) | FYNHIF1ACYP11B2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | BIOFOCUS DISCOVERY LTD. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | ROCK1, ROCK2, CIT | FYN 114/4885MKNK1 210/4885MKNK2 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.