Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 19/20 | 1.00 |
| ▸ | CDK4 | P11802 | 13/20 | 1.00 |
| ▸ | AURKA | O14965 | 6/20 | 1.00 |
| ▸ | CDK1 | P06493 | 6/20 | 1.00 |
| ▸ | CDK7 | P50613 | 6/20 | 1.00 |
| ▸ | CDK9 | P50750 | 6/20 | 1.00 |
| ▸ | AURKB | Q96GD4 | 5/20 | 1.00 |
| ▸ | PLK1 | P53350 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | PRKCG | P05129 | 1/20 | 0.58 |
| ▸ | PRKCB | P05771 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | PRKCA | P17252 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284344 | 0.90 | CDK2 (0.81) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL2289107 | 0.89 | CDK2 (0.80) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL4159675 | 0.89 | CDK2 (0.80) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL4802719 | 0.88 | CDK2 (0.79) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL4156619 | 0.88 | CDK2 (1.00) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL4163989 | 0.86 | CDK2 (0.75) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL2290750 | 0.85 | CDK2 (0.74) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL4154625 | 0.85 | CDK2 (1.00) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL2288182 | 0.85 | CDK2 (0.74) | CDK2CDK4AURKACDK1CDK7 | |
| SCHEMBL2289081 | 0.83 | CDK2 (0.76) | CDK2CDK4AURKACDK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | claimed |
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CYCLACEL LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137572-A1 | 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders | CDK2, CDK4, CDK20 | CDK2 1/4885CDK4 2/4885AURKA 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.