Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 4/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.66 |
| ▸ | KDM1A | O60341 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29768314 | 1.00 | PRCP (1.00) | PRCPSLC22A1ADRB2KDM1AGAA | |
| SCHEMBL5284097 | 1.00 | PRCP (1.00) | PRCPSLC22A1ADRB2KDM1AGAA | |
| SCHEMBL5812041 | 1.00 | PRCP (1.00) | PRCPSLC22A1ADRB2KDM1AGAA | |
| Hydrochloric Acid SCHEMBL8823234 | 0.98 | PRCP (0.97) | PRCPSLC22A1ADRB2KDM1AGAA | |
| Water SCHEMBL28203568 | 0.98 | PRCP (0.97) | PRCPSLC22A1ADRB2KDM1AGAA | |
| Urea SCHEMBL28457637 | 0.91 | PRCP (0.83) | PRCPSLC22A1ADRB2KDM1AGAA | |
| SCHEMBL10728169 | 0.87 | PRCP (0.77) | PRCPSLC22A1ADRB2KDM1AGAA | |
| SCHEMBL9411161 | 0.87 | PRCP (0.77) | PRCPSLC22A1ADRB2KDM1AOPRM1 | |
| SCHEMBL10728525 | 0.86 | PRCP (0.74) | PRCPSLC22A1ADRB2KDM1ASMN1; SMN2 | |
| SCHEMBL12859659 | 0.84 | PRCP (0.71) | PRCPSLC22A1KDM4EOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 189 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112920119-B | Preparation method of aporphine alkaloid | 中国药科大学 | 2023-05-23 | — | — | CN | claimed |
| CN-113004201-B | Aporphine alkaloid derivative and preparation method and medical application thereof | 中国药科大学 | 2022-08-05 | — | — | CN | claimed |
| CN-114075130-A | Benzoazaheterocycle compound and preparation method thereof | 复旦大学 | 2022-02-22 | — | — | CN | claimed |
| CN-113004201-A | Aporphine alkaloid derivative and preparation method and medical application thereof | 中国药科大学 | 2021-06-22 | — | — | CN | claimed |
| CN-112920119-A | Preparation method of aporphine alkaloid | 中国药科大学 | 2021-06-08 | — | — | CN | claimed |
| CN-111621819-B | Cyanide-free silver plating brightener and preparation method thereof | 广州三孚新材料科技股份有限公司 | 2021-04-20 | — | — | CN | claimed |
| CN-111621819-A | Cyanide-free silver plating brightener and preparation method thereof | 广州三孚新材料科技股份有限公司 | 2020-09-04 | — | — | CN | claimed |
| CN-108003099-A | A kind of double benzyl tetrahydro isoquinoline class compounds and its preparation method and application | 广东工业大学 | 2018-05-08 | — | — | CN | claimed |
| CN-103772405-A | Dibenzyl tetrahydroisoquinoline alkaloid as well as preparation method and application thereof | SHANGHAI INST PHARM INDUSTRY | 2014-05-07 | — | — | CN | claimed |
| CN-103772404-A | Dibenzyl tetrahydroisoquinoline derivative as well as preparation method and application thereof | SHANGHAI INST PHARM INDUSTRY | 2014-05-07 | — | — | CN | claimed |
| CN-1312132-C | 1-benzyl tetrahydro isoquinoline compound, its preparing process and use thereof | UNIV FUDAN (CN) | 2007-04-25 | — | — | CN | claimed |
| CN-1721408-A | 1-benzyl tetrahydro isoquinoline compound, its preparing process and use thereof | UNIV FUDAN (CN) | 2006-01-18 | — | — | CN | claimed |
| WO-1997036589-A9 | USE OF 1-BENZYL-1,2,3,4-TETRAHYHYDROISOQUINOLINE FOR THE MANUFACTURE OF A MEDICAMENT FOR IMPROVING CEREBRAL FUNCTION | — | 1997-12-31 | — | — | WO | claimed |
| WO-1997036589-A1 | USE OF 1-BENZYL-1,2,3,4-TETRAHYHYDROISOQUINOLINE FOR THE MANUFACTURE OF A MEDICAMENT FOR IMPROVING CEREBRAL FUNCTION | LEDERLE (JAPAN), LTD. (JP) | 1997-10-09 | — | — | WO | claimed |
| US-4657861-A | S-tetrahydroprotoberberineoxidase, process for producing the same and use thereof | CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) | 1987-04-14 | — | — | US | claimed |
| US-4556712-A | OPTICAL RESOLUTION THROUGH SALT FORMATION AND SOLUBILITY | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1985-12-03 | — | — | US | claimed |
| EP-0079383-A4 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION. | US SECRETARY UNITED STATES DEP (US) | 1984-01-12 | — | — | EP | claimed |
| US-4410700-A | Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1983-10-18 | — | — | US | claimed |
| EP-0079383-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) | 1983-05-25 | — | — | EP | claimed |
| WO-1982004049-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | US HEALTH (US) | 1982-11-25 | — | — | WO | claimed |