Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 8/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161852 | 1.00 | MIF (0.51) | MIFMAOBCYP26A1PSEN1PSEN2 | |
| SCHEMBL4170410 | 0.91 | MIF (0.56) | MIFMAOBCYP26A1CYP19A1MAOA | |
| SCHEMBL4170407 | 0.91 | MIF (0.56) | MIFMAOBCYP26A1CYP19A1MAOA | |
| SCHEMBL6239187 | 0.87 | MIF (0.64) | MIFMAOBCYP26A1CYP19A1CYP11B1 | |
| SCHEMBL4156050 | 0.86 | MIF (0.55) | MIFMAOBCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8348970 | 0.86 | MIF (0.55) | MIFMAOBCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL4156051 | 0.86 | MIF (0.55) | MIFMAOBCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL14092251 | 0.86 | MAOB (0.48) | MAOBCYP19A1CYP11B1CYP11B2HTT | |
| SCHEMBL4162515 | 0.84 | CYP19A1 (0.46) | MAOBCYP19A1CYP11B1CYP11B2HTT | |
| SCHEMBL4162518 | 0.84 | CYP19A1 (0.46) | MAOBCYP19A1CYP11B1CYP11B2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149445-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | COGHLAN MICHAEL JOSEPH | 2009-06-11 | — | — | US | disclosed |
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-20060063759-A1 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149445-A1 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | NR5A1, NR3C2, NR3C1 | MIF 1642/4885MAOB 2154/4885CYP26A1 110/4885 |
| US-20060063759-A1 | Tricyclic steroid hormone nuclear receptor modulators | NR5A1, NR3C2, NR3C1 | MIF 1592/4885MAOB 2012/4885CYP26A1 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.