Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929097 | 0.88 | AAK1 (0.32) | AAK1 | |
| SCHEMBL4172027 | 0.87 | AAK1 (0.33) | SSTR4AAK1EGFRAURKB | |
| SCHEMBL3941385 | 0.86 | GPR119 (0.37) | — | |
| SCHEMBL4502806 | 0.85 | MAP2K1 (0.33) | MAP2K1 | |
| SCHEMBL3937105 | 0.81 | AAK1 (0.32) | AAK1 | |
| SCHEMBL3929669 | 0.77 | GPR119 (0.36) | — | |
| SCHEMBL3934886 | 0.75 | GPR119 (0.37) | — | |
| SCHEMBL3934441 | 0.74 | GPR119 (0.38) | — | |
| SCHEMBL3930864 | 0.74 | GPR119 (0.36) | — | |
| SCHEMBL4162417 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043744-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008895-A1 | GPR119 AGONISTS FOR THE TREATMENT OF DIABETES AND RELATED DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008008887-A2 | GPR119 AGONISTS FOR TREATING METABOLIC DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |