Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.76 |
| ▸ | IGF1R | P08069 | 4/20 | 0.70 |
| ▸ | KIT | P10721 | 1/20 | 0.69 |
| ▸ | SGK1 | O00141 | 2/20 | 0.67 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.62 |
| ▸ | CLK1 | P49759 | 1/20 | 0.62 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.62 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.62 |
| ▸ | LYN | P07948 | 2/20 | 0.60 |
| ▸ | SYK | P43405 | 2/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | CHUK | O15111 | 1/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.60 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.59 |
| ▸ | AXL | P30530 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4167572 | 0.90 | NTRK1 (0.79) | NTRK1IGF1RKITSGK1TNIK | |
| SCHEMBL3763379 | 0.89 | NTRK1 (0.80) | NTRK1IGF1RKITSGK1TNIK | |
| SCHEMBL17319204 | 0.89 | NTRK1 (0.80) | NTRK1IGF1RKITSGK1TNIK | |
| SCHEMBL3775679 | 0.88 | NTRK1 (0.76) | NTRK1IGF1RKITSGK1TNIK | |
| SCHEMBL3766005 | 0.87 | NTRK1 (0.77) | NTRK1IGF1RKITSGK1TNIK | |
| SCHEMBL3760839 | 0.86 | NTRK1 (1.00) | NTRK1IGF1RKITTNIKDYRK1A | |
| SCHEMBL3768119 | 0.85 | RIPK1 (0.81) | NTRK1IGF1RKITSGK1TNIK | |
| SCHEMBL4160145 | 0.84 | NTRK1 (0.77) | NTRK1IGF1RKITTNIKDYRK1A | |
| SCHEMBL3761694 | 0.84 | NTRK1 (0.84) | NTRK1IGF1RKITTNIKDYRK1A | |
| SCHEMBL3807981 | 0.84 | SGK1 (0.67) | NTRK1IGF1RKITSGK1TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | claimed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | claimed |
| WO-2021006707-A1 | USE OF SGK1 INHIBITOR AS THERAPEUTIC AGENT FOR INFLAMMATORY NEUROLOGICAL DISEASES | 한양대학교 산학협력단 | 2021-01-14 | — | — | WO | disclosed |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | disclosed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | NTRK1 964/4885IGF1R 1254/4885KIT 1364/4885 |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | SGK1, SGK2, SGK3 | NTRK1 997/4885IGF1R 1281/4885KIT 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.