Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | ATR | Q13535 | 19/20 | 0.45 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | TAF1 | P21675 | 2/20 | 0.38 |
| ▸ | PRKDC | P78527 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4205311 | 1.00 | MTOR (0.53) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4198487 | 0.89 | ATR (0.54) | MTORPIK3CAATRATRIPKCNH2 | |
| SCHEMBL4212952 | 0.88 | MTOR (0.67) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4207591 | 0.86 | MTOR (0.65) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4200873 | 0.85 | MTOR (0.64) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4207774 | 0.85 | ATR (0.47) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4168167 | 0.85 | ATR (0.47) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4208012 | 0.84 | MTOR (0.63) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4201316 | 0.84 | MTOR (0.63) | MTORPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4201935 | 0.84 | MTOR (0.63) | MTORPIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074118-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | AstraZeneca AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |