Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7071047 | 0.85 | AAK1 (0.48) | CA12CA1CA9CYP17A1NR1I3 | |
| SCHEMBL3789950 | 0.84 | CA12 (0.48) | MEN1KMT2AALDH1A1CA12CA1 | |
| SCHEMBL4299949 | 0.83 | MEN1 (0.44) | MEN1KMT2AALDH1A1LMNACA12 | |
| SCHEMBL4168732 | 0.82 | KMT2A (0.62) | MEN1KMT2AALDH1A1LMNACA12 | |
| SCHEMBL7078118 | 0.81 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL5562128 | 0.79 | AAK1 (0.44) | MEN1KMT2ACA12CA1CA9 | |
| SCHEMBL16303890 | 0.78 | EPHX1 (0.58) | MEN1KMT2AALDH1A1LMNACA12 | |
| SCHEMBL18757717 | 0.78 | HSP90AA1 (0.42) | MEN1KMT2AALDH1A1LMNACA12 | |
| SCHEMBL30306445 | 0.78 | HSP90AA1 (0.42) | MEN1KMT2AALDH1A1LMNACA12 | |
| SCHEMBL6680965 | 0.77 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1LMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009089042-A1 | PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2009-07-16 | — | — | WO | disclosed |