Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 7/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4150426 | 0.93 | TGFBR1 (0.44) | TGFBR1CYP3A4CYP2C8NEK1TGFBR2 | |
| SCHEMBL3803691 | 0.77 | TGFBR1 (0.43) | TGFBR1CYP3A4CYP2C8NEK1TGFBR2 | |
| SCHEMBL4155519 | 0.76 | TGFBR1 (0.45) | TGFBR1CYP3A4CYP2C8NEK1TGFBR2 | |
| SCHEMBL4167174 | 0.75 | CYP3A4 (0.43) | TGFBR1CYP3A4CYP2C8PRKCQPRKCD | |
| SCHEMBL4171887 | 0.75 | TGFBR1 (0.51) | TGFBR1CYP3A4CYP2C8TGFBR2MAPK14 | |
| SCHEMBL4150483 | 0.75 | TGFBR1 (0.49) | TGFBR1CYP3A4CYP2C8TGFBR2CCR1 | |
| SCHEMBL3808160 | 0.74 | TGFBR1 (0.42) | TGFBR1CYP3A4CYP2C8TGFBR2JAK1 | |
| SCHEMBL4157242 | 0.74 | TGFBR1 (0.50) | TGFBR1CYP3A4CYP2C8TGFBR2MAPK14 | |
| SCHEMBL4168756 | 0.74 | TGFBR1 (0.58) | TGFBR1CYP3A4CYP2C8TGFBR2 | |
| SCHEMBL3664985 | 0.73 | TGFBR1 (0.47) | TGFBR1CYP3A4CYP2C8TGFBR2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | ALK, ACVR1, PTPN4 | TGFBR1 128/4885CYP3A4 111/4885CYP2C8 1297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.