Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propranolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 8/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 7/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 6/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | HTR2C | P28335 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | HTR1A | P08908 | 4/20 | 1.00 |
| ▸ | HTR2A | P28223 | 3/20 | 1.00 |
| ▸ | HTR6 | P50406 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.97 |
| ▸ | NR2E1 | Q9Y466 | 5/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propranolol SCHEMBL9064508 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 | |
| Propranolol SCHEMBL29349844 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 | |
| Dexpropranolol SCHEMBL610656 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 | |
| Propranolol SCHEMBL17838091 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 | |
| Levopropranolol SCHEMBL41689 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 | |
| Propranolol SCHEMBL1553064 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 | |
| Dexpropranolol SCHEMBL30309315 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 | |
| Levopropranolol SCHEMBL30530984 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 | |
| Propranolol SCHEMBL9183224 | 0.99 | ADRB2 (0.97) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 | |
| Propranolol SCHEMBL7397696 | 0.99 | ADRB2 (0.97) | ADRB2ADRB1ADRB3SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 20436 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4709378-A1 | COMPOUNDS FOR NOS-RELATED CANCERS AND METHODS OF USE | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2026-03-18 | — | — | EP | claimed |
| US-20260041823-A1 | IMPLANTABLE MATERIAL AND SYNTHESIS METHOD THEREFOR AND PROSTHETIC HEART VALVE | VENUS MEDTECH HANGZHOU INC (CN) | 2026-02-12 | — | — | US | claimed |
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| EP-4687837-A1 | AN ORALLY RAPIDLY DISINTEGRATING TABLET OF PROPRANOLOL AND ITS PROCESS OF PREPARATION | Novumgen Limited (GB) | 2026-02-11 | — | — | EP | claimed |
| US-20250387343-A1 | Nanoparticle Compositions and Methods for Synthesis Thereof | ICEUTICA PTY LTD (AU) | 2025-12-25 | — | — | US | claimed |
| US-20250264469-A1 | METHODS FOR IMPROVING OUTCOMES FOR HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS AT RISK FOR BRONCHIOLITIS OBLITERANS SYNDROME | CHILDREN'S HOSPITAL MEDICAL CENTER | 2025-08-21 | — | — | US | claimed |
| US-20250242046-A1 | ALLOGENEIC HYPOIMMUNE BIOMIMETIC NANOVESICLE FOR THE TREATMENT OF CANCER | MALCOLM THOMAS (US) | 2025-07-31 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-4378534-A | Wideband modulation sensitivity compensated voltage controlled oscillator | MOTOROLA, INC. (US) | 1983-03-29 | — | — | US | claimed |
| US-4309405-A | Sustained release pharmaceutical compositions | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-01-05 | — | — | US | claimed |
| US-4309404-A | CORE CONTAINING A DRUG, SEAL COATING, SUGAR OVERCOATING | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-01-05 | — | — | US | claimed |
| US-4309406-A | CORE CONTAINING A DRUG, SEAL COATING, SUGAR OVERCOATING | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-01-05 | — | — | US | claimed |
| US-4287194-A | Compositions with potentiated hypotensive effects | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1981-09-01 | — | — | US | claimed |
| EP-0023704-A2 | Novel dosage forms containing propanolol | The University of Kentucky Research Foundation (US) | 1981-02-11 | — | — | EP | claimed |
| US-4248858-A | COMPRISING A CORE OF PROPRANOLOL, A CELLULOSE DERIVATIVE AND ETHYL CELLULOSE, AN ENTERIC COATING AND A SUGAR COATING CONTAINING PROPRANOLOL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-02-03 | — | — | US | claimed |
| US-4248856-A | COMPRISING A CELLULOSIC CORE, SUGAR COATING AND HAVING PROPRANOLOL IN BOTH | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-02-03 | — | — | US | claimed |
| US-4248857-A | PROPRANOLOL AND SUGAR COATING ON A CORE OF PROPRANOLOL, POLYACRYLIC ACID, STEARIC ACID AND MANNITOL; ENERGIC BLOCKING AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-02-03 | — | — | US | claimed |
| US-4138475-A | Sustained release pharmaceutical composition | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-02-06 | — | — | US | claimed |