Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4172670 | 0.90 | TGFBR1 (0.69) | TGFBR1CDK2 | |
| SCHEMBL4177684 | 0.89 | TGFBR1 (0.68) | TGFBR1 | |
| SCHEMBL4174942 | 0.88 | TGFBR1 (0.67) | TGFBR1CDK2 | |
| SCHEMBL4172942 | 0.86 | TGFBR1 (0.79) | TGFBR1 | |
| SCHEMBL3949452 | 0.85 | TGFBR1 (0.63) | TGFBR1 | |
| SCHEMBL4172692 | 0.85 | TGFBR1 (0.63) | TGFBR1 | |
| SCHEMBL4171647 | 0.85 | TGFBR1 (0.63) | TGFBR1 | |
| SCHEMBL3951081 | 0.84 | TGFBR1 (0.62) | TGFBR1CDK2 | |
| SCHEMBL4174543 | 0.84 | TGFBR1 (0.82) | TGFBR1 | |
| SCHEMBL4184161 | 0.84 | TGFBR1 (0.61) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | TGFBR1, TGFBR2, SMAD3 | TGFBR1 1/4885CDK2 2833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.