Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 19/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 14/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.49 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147140 | 0.82 | ADORA2B (0.71) | ADORA2BADORA2AADORA3ADORA1PLK4 | |
| SCHEMBL1947236 | 0.78 | ADORA2B (0.79) | ADORA2BADORA2AADORA3ADORA1PLK4 | |
| SCHEMBL1944491 | 0.76 | ADORA2B (0.71) | ADORA2BADORA2AADORA3ADORA1PLK4 | |
| SCHEMBL1944916 | 0.75 | ADORA2B (0.82) | ADORA2BADORA2AADORA3ADORA1PLK4 | |
| SCHEMBL1724513 | 0.74 | ADORA2B (0.55) | ADORA2BADORA2AADORA3ADORA1PLK4 | |
| SCHEMBL1446900 | 0.73 | ADORA2B (0.70) | ADORA2BADORA2AADORA3ADORA1PLK4 | |
| SCHEMBL1697135 | 0.73 | ADORA2B (0.64) | ADORA2BADORA2AADORA3ADORA1PLK4 | |
| SCHEMBL1724705 | 0.73 | ADORA2B (0.58) | ADORA2BADORA2AADORA3ADORA1PLK4 | |
| SCHEMBL242942 | 0.73 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1PLK4 | |
| SCHEMBL1945825 | 0.72 | ADORA2B (1.00) | ADORA2BADORA2AADORA3ADORA1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009088518-A1 | A2B ADENOSINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CANCER | CV THERAPEUTICS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |