Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 17/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4171243 | 1.00 | GRIA2 (0.51) | GRIA2KCNH2GRIA4CYP1A2 | |
| SCHEMBL4171246 | 1.00 | GRIA2 (0.51) | GRIA2KCNH2GRIA4CYP1A2 | |
| SCHEMBL30794614 | 0.90 | GRIA2 (0.45) | GRIA2KCNH2GRIA4CYP1A2 | |
| SCHEMBL4177564 | 0.88 | GRIA2 (0.66) | GRIA2KCNH2GRIA4 | |
| SCHEMBL4177562 | 0.88 | GRIA2 (0.66) | GRIA2KCNH2GRIA4 | |
| SCHEMBL4177559 | 0.88 | GRIA2 (0.66) | GRIA2KCNH2GRIA4 | |
| SCHEMBL30795743 | 0.88 | GRIA2 (0.66) | GRIA2KCNH2GRIA4 | |
| SCHEMBL4177821 | 0.83 | GRIA2 (0.52) | GRIA2KCNH2GRIA4CYP1A2 | |
| SCHEMBL4177823 | 0.83 | GRIA2 (0.52) | GRIA2KCNH2GRIA4CYP1A2 | |
| SCHEMBL4177820 | 0.83 | GRIA2 (0.52) | GRIA2KCNH2GRIA4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170902-A1 | COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | US | claimed |
| US-20090170902-A1 | COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | US | disclosed |
| US-20080139472-A1 | UPREGULATING BDNF LEVELS TO MITIGATE MENTAL RETARDATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170902-A1 | COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE | GRIN1, GRM1, GRIN2C | GRIA2 16/4885KCNH2 1455/4885GRIA4 8/4885 |
| US-20080139472-A1 | UPREGULATING BDNF LEVELS TO MITIGATE MENTAL RETARDATION | BDNF, MECP2, NTRK2 | GRIA2 43/4885KCNH2 4187/4885GRIA4 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.