Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.50 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946680 | 0.82 | PDE10A (0.52) | PDE10AHPGDSSMN1; SMN2LMNAPOLB | |
| SCHEMBL4192021 | 0.81 | PDE10A (0.52) | PDE10AHPGDSCYP11B2PIK3CAMTOR | |
| SCHEMBL20606514 | 0.75 | MAOB (0.42) | SMN1; SMN2POLBMAPTKDM4EGAA | |
| SCHEMBL15539728 | 0.75 | CHRNB2 (0.43) | POLB | |
| SCHEMBL4159979 | 0.72 | PDE10A (0.43) | PDE10AHPGDSSMN1; SMN2LMNACYP11B2 | |
| SCHEMBL4195075 | 0.71 | PDE10A (0.54) | PDE10AHPGDSSMN1; SMN2LMNACYP11B2 | |
| SCHEMBL16467124 | 0.69 | PDE10A (0.51) | PDE10AHPGDSCYP11B2PIK3CAMTOR | |
| SCHEMBL3955964 | 0.68 | PDE10A (1.00) | PDE10A | |
| SCHEMBL13909589 | 0.68 | PDE10A (0.77) | PDE10A | |
| SCHEMBL16795172 | 0.66 | ALK (0.38) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029214-A1 | ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2009-03-05 | — | — | WO | disclosed |
| US-20090062291-A1 | PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. | 2009-03-05 | — | — | US | disclosed |
| US-20090054434-A1 | ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2009-02-26 | — | — | US | disclosed |
| WO-2009025839-A2 | PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062291-A1 | PHOSPHODIESTERASE 10 INHIBITORS | PDE10A, PDE12, PDE5A | PDE10A 1/4885HPGDS 3364/4885SMN1; SMN2 4698/4885 |
| US-20090054434-A1 | ISOQUINOLONE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | PDE5A, PDE4A, PDE4B | PDE10A 8/4885HPGDS 2513/4885SMN1; SMN2 4641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.