Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.70 |
| ▸ | KIT | P10721 | 7/20 | 0.70 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.67 |
| ▸ | CLK1 | P49759 | 2/20 | 0.67 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.66 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.66 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.66 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | CDK9 | P50750 | 1/20 | 0.66 |
| ▸ | AXL | P30530 | 1/20 | 0.62 |
| ▸ | CDK8 | P49336 | 1/20 | 0.62 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.62 |
| ▸ | SGK1 | O00141 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17319207 | 0.87 | KIT (0.69) | NTRK1KITDYRK1ACLK1DYRK2 | |
| SCHEMBL3764839 | 0.87 | AXL (0.83) | NTRK1KITMAP3K11DYRK1ACLK1 | |
| SCHEMBL3769503 | 0.84 | AXL (0.75) | NTRK1KITMAP3K11DYRK1ACDK2 | |
| SCHEMBL8320028 | 0.84 | AXL (0.78) | NTRK1KITMAP3K11CDK2AXL | |
| SCHEMBL4157255 | 0.83 | AXL (0.80) | NTRK1KITDYRK1ACLK1DYRK2 | |
| SCHEMBL17319205 | 0.82 | KIT (0.69) | NTRK1KITDYRK1ACLK1DYRK2 | |
| SCHEMBL12763289 | 0.82 | KIT (0.66) | NTRK1KITDYRK1ACLK1DYRK2 | |
| SCHEMBL3769633 | 0.82 | NTRK1 (0.76) | NTRK1KITMAP3K11DYRK1ACLK1 | |
| SCHEMBL8320989 | 0.81 | AXL (0.83) | NTRK1KITMAP3K11DYRK1ACLK1 | |
| SCHEMBL722564 | 0.81 | MAP3K11 (1.00) | NTRK1KITMAP3K11DYRK1ACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | claimed |
| WO-2021006707-A1 | USE OF SGK1 INHIBITOR AS THERAPEUTIC AGENT FOR INFLAMMATORY NEUROLOGICAL DISEASES | 한양대학교 산학협력단 | 2021-01-14 | — | — | WO | disclosed |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | GlaxoSmithKline, LLC | 2012-09-20 | — | — | US | disclosed |
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | GLAXOSMITHKLINE LLC | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233955-A1 | 1H-Pyrrolo[2,3-B]Pyridnes | SGK1, SGK2, SGK3 | NTRK1 964/4885KIT 1364/4885MAP3K11 56/4885 |
| US-20120238588-A1 | 1H-Pyrrolo[2,3-B]Pyridines | SGK1, SGK2, SGK3 | NTRK1 997/4885KIT 1240/4885MAP3K11 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.