Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 17/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15384081 | 0.94 | POLB (0.46) | POLBCFTRADORA3ADRB3TBXA2R | |
| SCHEMBL15384944 | 0.90 | CFTR (0.46) | POLBCFTRADORA3ADRB3TBXA2R | |
| SCHEMBL4191680 | 0.89 | CFTR (0.50) | POLBCFTRADORA3ADRB3TBXA2R | |
| SCHEMBL4169561 | 0.89 | CFTR (0.49) | POLBCFTRADORA3ADRB3TBXA2R | |
| SCHEMBL4169558 | 0.89 | CFTR (0.49) | POLBCFTRADORA3ADRB3TBXA2R | |
| SCHEMBL4169563 | 0.89 | CFTR (0.49) | POLBCFTRADORA3ADRB3TBXA2R | |
| SCHEMBL4174381 | 0.86 | POLB (0.43) | POLBCFTRADORA3ADRB3TBXA2R | |
| SCHEMBL4177253 | 0.85 | CFTR (0.62) | CFTRADORA3ADRB3TBXA2RSLC6A2 | |
| SCHEMBL394207 | 0.84 | CFTR (0.66) | POLBCFTRADORA3ADRB3TBXA2R | |
| SCHEMBL13877209 | 0.82 | CFTR (0.47) | POLBCFTRADORA3ADRB3TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336898-A1 | Prodrugs of Modulators of ABC Transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2015-11-26 | — | — | US | disclosed |
| US-20140243289-A1 | PRODRUGS OF MODULATORS OF ABC TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-28 | — | — | US | disclosed |
| US-20130303484-A1 | Prodrugs of Modulators of ABC Transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2013-11-14 | — | — | US | disclosed |
| US-20090105272-A1 | Prodrugs of modulators of ABC transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2009-04-23 | — | — | US | disclosed |
| US-20090105272-A1 | Prodrugs of modulators of ABC transporters | VERTEX PHARMACEUTICALS INCORPORATED | 2009-04-23 | — | — | US | disclosed |
| EP-1979367-A2 | QUINOLIN-4-ONE DERIVATIVES AS MODULATORS OF ABC TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007075901-A2 | QUINOLIN- 4 - ONE DERIVATIVES AS MODULATORS OF ABC TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105272-A1 | Prodrugs of modulators of ABC transporters | ABCB1, CFTR, ABCB11 | POLB 1787/4885CFTR 2/4885ADORA3 364/4885 |
| US-20130303484-A1 | Prodrugs of Modulators of ABC Transporters | ABCB1, CFTR, ABCB11 | POLB 1787/4885CFTR 2/4885ADORA3 364/4885 |
| US-20150336898-A1 | Prodrugs of Modulators of ABC Transporters | ABCB1, CFTR, ABCB11 | POLB 1787/4885CFTR 2/4885ADORA3 364/4885 |
| US-20140243289-A1 | PRODRUGS OF MODULATORS OF ABC TRANSPORTERS | ABCB1, CFTR, ABCB11 | POLB 1787/4885CFTR 2/4885ADORA3 364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.