Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (R,R)-Tramadol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.98 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.98 |
| ▸ | MEN1 | O00255 | 2/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R,R)-Tramadol SCHEMBL29625842 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL429520 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL405854 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL7141021 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL1377516 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL405853 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL7137387 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Tramadol SCHEMBL6052999 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Tramadol SCHEMBL405855 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL6543502 | 1.00 | SLC6A2 (0.98) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7241 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12514833-B2 | Combination of ibuprofen and tramadol for relieving pain | FARMALÍDER, S.A. (ES) | 2026-01-06 | — | — | US | claimed |
| US-20250228797-A1 | SYNERGIC AND STABLE PHARMACEUTICAL COMPOSITION OF AN NSAID AND AN OPIOID ANALGESIC FOR PAIN AND INFLAMMATION | LABORATORIOS SILANES S A DE C V (MX) | 2025-07-17 | — | — | US | claimed |
| EP-4585207-A1 | SYNERGIC AND STABLE PHARMACEUTICAL COMPOSITION OF AN NSAID AND AN OPIOID ANALGESIC FOR PAIN AND INFLAMMATION | Laboratorios Silanes, S.A. de C.V. (MX) | 2025-07-16 | — | — | EP | claimed |
| US-12337065-B2 | Compositions for treating viral infections and methods for same | ACCESS TO ADVANCED HEALTH INSTITUTE (US) | 2025-06-24 | — | — | US | claimed |
| EP-4566590-A1 | TASTE-MASKING MICROSPHERE, PREPARATION PROCESS THEREFOR, AND USE THEREOF | Harbin Kanon Pharmaceutical Co., Ltd (CN) | 2025-06-11 | — | — | EP | claimed |
| CN-119947714-A | Ionic bond compound of perubiprofen and tramadol, composition containing the same and preparation method thereof | 大元制药株式会社 | 2025-05-06 | — | — | CN | claimed |
| CN-119606905-A | Multi-unit sustained release tablet and preparation method thereof | 南通联亚药业股份有限公司 | 2025-03-14 | — | — | CN | claimed |
| WO-2025050227-A1 | ASSEMBLABLE, COMPACTABLE, REUSEABLE AND RECYCLABLE CARDBOARD PALLET FOR TRANSPORTING AND STORING MERCHANDISE | STANLEY CALVO ROBERTO TOMAS (CL) | 2025-03-13 | — | — | WO | claimed |
| EP-4489771-A2 | METHODS OF TREATING HEMOPHILIA A | Bioverativ Therapeutics Inc. (US) | 2025-01-15 | — | — | EP | claimed |
| CN-118984716-A | Methods of treating hemophilia a | 比奥维拉迪维治疗股份有限公司 | 2024-11-19 | — | — | CN | claimed |
| US-5395626-A | Containing hydroxypropyl methyl cellulose, polyoxyethylene glycol, ethyl cellulose and active drug | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-03-07 | — | — | US | claimed |
| EP-0624366-A1 | Controlled release formulation containing tramadol | Euroceltique S.A. (LU) | 1994-11-17 | — | — | EP | claimed |
| US-5336691-A | Treating pain and tussive conditions | MCNEILAB, INC. (US) | 1994-08-09 | — | — | US | claimed |
| EP-0566709-A4 | — | — | 1994-04-06 | — | — | EP | claimed |
| EP-0566709-A1 | COMPOSITION COMPRISING A TRAMADOL COMPOUND AND ACETAMINOPHEN, AND ITS USE | MCNEILAB, INC. (US) | 1993-10-27 | — | — | EP | claimed |
| EP-0546676-A1 | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug | MCNEILAB, INC. (US) | 1993-06-16 | — | — | EP | claimed |
| CN-1073095-A | The compositions that contains a kind of tramadol composition and a kind of nonsteroidal anti-inflammatory drug | MCNEILAB INC (US) | 1993-06-16 | — | — | CN | claimed |
| EP-0534628-A1 | Compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone, and their use | MCNEILAB, INC. (US) | 1993-03-31 | — | — | EP | claimed |
| WO-1993004675-A1 | COMPOSITION COMPRISING A TRAMADOL MATERIAL AND ACETAMINOPHEN AND ITS USE | MCNEILAB, INC. (US) | 1993-03-18 | — | — | WO | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |