Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Fructose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fructose SCHEMBL27819910 | 0.98 | CYP2C9 (0.54) | LMNACYP2C9TSHRPDE4AL3MBTL1 | |
| Fructose SCHEMBL421839 | 0.98 | CYP2C9 (0.54) | LMNACYP2C9TSHRPDE4AL3MBTL1 | |
| Fructose SCHEMBL7531716 | 0.98 | CYP2C9 (0.54) | LMNACYP2C9TSHRPDE4AL3MBTL1 | |
| Fructose SCHEMBL5436569 | 0.95 | CYP2C9 (0.52) | LMNACYP2C9TSHRPDE4AL3MBTL1 | |
| Fructose SCHEMBL7549336 | 0.95 | CYP2C9 (0.56) | LMNACYP2C9TSHRPDE4AL3MBTL1 | |
| Fructose SCHEMBL159418 | 0.95 | CYP2C9 (0.56) | LMNACYP2C9TSHRPDE4AL3MBTL1 | |
| Fructose SCHEMBL80090 | 0.95 | CYP2C9 (0.56) | LMNACYP2C9TSHRPDE4AL3MBTL1 | |
| Tagatose SCHEMBL7524214 | 0.95 | CYP2C9 (0.56) | LMNACYP2C9TSHRPDE4AL3MBTL1 | |
| Fructose SCHEMBL7707744 | 0.95 | CYP2C9 (0.56) | LMNACYP2C9TSHRPDE4AL3MBTL1 | |
| Fructose SCHEMBL19744235 | 0.95 | CYP2C9 (0.56) | LMNACYP2C9TSHRPDE4AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090056729-A1 | SMOKING ARTICLE AND SMOKING ARTICLE FILTER | ZAWADZKI MICHAEL A | 2009-03-05 | — | — | US | disclosed |
| EP-1624765-A2 | SMOKING ARTICLE AND SMOKING ARTICLE FILTER | Lorillard Licensing Company, Llc (US) | 2006-02-15 | — | — | EP | disclosed |
| WO-2004103099-A2 | SMOKING ARTICLE AND SMOKING ARTICLE FILTER | LORILLARD LICENSING COMPANY, LLC (US) | 2004-12-02 | — | — | WO | disclosed |
| US-20040231684-A1 | Smoking article and smoking article filter | LORILLARD LICENSING COMPANY, LLC | 2004-11-25 | — | — | US | disclosed |