Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 14/20 | 1.00 |
| ▸ | CACNB1 | Q02641 | 14/20 | 1.00 |
| ▸ | CACNA1A | O00555 | 2/20 | 1.00 |
| ▸ | CACNA1B | Q00975 | 13/20 | 0.83 |
| ▸ | CACNA1C | Q13936 | 12/20 | 0.83 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.83 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5265363 | 0.91 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL5267690 | 0.91 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL8427763 | 0.91 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL13569213 | 0.86 | CACNA2D1 (0.85) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL5547413 | 0.85 | CACNA2D1 (0.74) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL3426145 | 0.82 | CACNA2D1 (0.70) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL5264964 | 0.82 | CACNA2D1 (0.85) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL5267046 | 0.82 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL4352704 | 0.82 | CACNA2D1 (0.78) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C | |
| SCHEMBL4182732 | 0.81 | CACNA2D1 (1.00) | CACNA2D1CACNB1CACNA1ACACNA1BCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362021-B2 | Method for increasing the bioavailability of benzhydryl piperazine containing compounds | ZALICUS PHARMACEUTICALS LTD. (CA) | 2013-01-29 | — | — | US | claimed |
| US-20090312346-A1 | METHOD FOR INCREASING THE BIOAVAILABILITY OF BENZHYDRYL PIPERAZINE CONTAINING COMPOUNDS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-12-17 | — | — | US | claimed |
| EP-2019676-A2 | METHOD FOR INCREASING THE BIOAVAILABILITY OF BENZHYDRYL PIPERAZINE CONTAINING COMPOUNDS | Neuromed Pharmaceuticals, Ltd. (CA) | 2009-02-04 | — | — | EP | claimed |
| WO-2007133481-A2 | METHOD FOR INCREASING THE BIOAVAILABILITY OF BENZHYDRYL PIPERAZINE CONTAINING COMPOUNDS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-11-22 | — | — | WO | claimed |
| US-8362021-B2 | Method for increasing the bioavailability of benzhydryl piperazine containing compounds | ZALICUS PHARMACEUTICALS LTD. (CA) | 2013-01-29 | — | — | US | disclosed |
| US-8362021-B2 | Method for increasing the bioavailability of benzhydryl piperazine containing compounds | ZALICUS PHARMACEUTICALS LTD. (CA) | 2013-01-29 | — | — | US | disclosed |
| US-8362021-B2 | Method for increasing the bioavailability of benzhydryl piperazine containing compounds | ZALICUS PHARMACEUTICALS LTD. (CA) | 2013-01-29 | — | — | US | disclosed |
| US-20090312346-A1 | METHOD FOR INCREASING THE BIOAVAILABILITY OF BENZHYDRYL PIPERAZINE CONTAINING COMPOUNDS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-12-17 | — | — | US | disclosed |
| US-20090312346-A1 | METHOD FOR INCREASING THE BIOAVAILABILITY OF BENZHYDRYL PIPERAZINE CONTAINING COMPOUNDS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-12-17 | — | — | US | disclosed |
| WO-2007133481-A2 | METHOD FOR INCREASING THE BIOAVAILABILITY OF BENZHYDRYL PIPERAZINE CONTAINING COMPOUNDS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312346-A1 | METHOD FOR INCREASING THE BIOAVAILABILITY OF BENZHYDRYL PIPERAZINE CONTAINING COMPOUNDS | SLC7A1, SLC10A2, SLC10A1 | CACNA2D1 3029/4885CACNB1 1150/4885CACNA1A 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.