Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.65 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DBH | P09172 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3260891 | 0.80 | NPC1 (0.71) | CYP11B1CYP11B2NPC1RAB9AALDH1A1 | |
| SCHEMBL24845216 | 0.79 | CYP11B1 (0.58) | CYP11B1CYP11B2NPC1RAB9AALDH1A1 | |
| SCHEMBL9747422 | 0.79 | CYP11B1 (1.00) | CYP11B1CYP11B2POLB | |
| SCHEMBL3383923 | 0.77 | CYP11B1 (0.65) | CYP11B1CYP11B2 | |
| SCHEMBL16129815 | 0.77 | CYP11B1 (0.65) | CYP11B1CYP11B2SMN1; SMN2TAAR1IDO1 | |
| SCHEMBL25583831 | 0.76 | CYP11B1 (0.55) | CYP11B1CYP11B2NPC1RAB9AALDH1A1 | |
| SCHEMBL2979521 | 0.76 | CYP11B1 (0.55) | CYP11B1CYP11B2NPC1RAB9AALDH1A1 | |
| SCHEMBL24845219 | 0.76 | CYP11B1 (0.55) | CYP11B1CYP11B2NPC1RAB9AALDH1A1 | |
| SCHEMBL27999080 | 0.76 | GABRG2 (0.43) | CYP11B1CYP11B2NPC1RAB9APOLB | |
| SCHEMBL28174118 | 0.75 | CYP19A1 (0.60) | CYP11B1CYP11B2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |