Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 9/20 | 0.83 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl Fumarate SCHEMBL4179975 | 1.00 | HCAR2 (0.83) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| Ethyl Fumarate SCHEMBL28185445 | 1.00 | HCAR2 (0.83) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| Ethyl Fumarate SCHEMBL18863283 | 0.94 | HCAR2 (0.74) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| Ethyl Fumarate SCHEMBL502319 | 0.91 | HCAR2 (0.91) | HCAR2MAPTLMNAMDM2MDM4 | |
| Diethyl Maleate SCHEMBL1997508 | 0.91 | HCAR2 (0.67) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| Ethyl Fumarate SCHEMBL60569 | 0.91 | HCAR2 (1.00) | HCAR2MAPTALDH1A1LMNAMDM2 | |
| SCHEMBL847081 | 0.91 | HCAR2 (0.67) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| Ethyl Fumarate SCHEMBL1133858 | 0.91 | HCAR2 (1.00) | HCAR2MAPTALDH1A1LMNAMDM2 | |
| Diethyl Maleate SCHEMBL10994278 | 0.91 | HCAR2 (1.00) | HCAR2MAPTALDH1A1LMNAMDM2 | |
| Diethyl Maleate SCHEMBL19873394 | 0.91 | HCAR2 (1.00) | HCAR2MAPTALDH1A1LMNAMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090142593-A1 | PRESSURE-SENSITIVE ADHESIVE TAPE | NITTO DENKO CORPORATION (JP) | 2009-06-04 | — | — | US | disclosed |
| EP-0467168-A2 | Aqueous preparations from copolymer latices and polyisocyanate dispersions | BASF Aktiengesellschaft (DE) | 1992-01-22 | — | — | EP | disclosed |