Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.48 |
| ▸ | PDE4A | P27815 | 6/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4180302 | 1.00 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CL3MBTL1 | |
| SCHEMBL7206772 | 0.87 | TSHR (0.50) | PDE4DPDE4APDE4BPDE4CL3MBTL1 | |
| SCHEMBL7206773 | 0.87 | TSHR (0.50) | PDE4DPDE4APDE4BPDE4CL3MBTL1 | |
| SCHEMBL4176914 | 0.84 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CL3MBTL1 | |
| SCHEMBL4183508 | 0.82 | KMT2A (0.53) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL4194071 | 0.78 | PDE4D (0.58) | PDE4DALDH1A1MAPTTSHRPOLB | |
| SCHEMBL7205749 | 0.77 | PDE4D (0.57) | PDE4DPDE4APDE4BPDE4CL3MBTL1 | |
| SCHEMBL4190701 | 0.77 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CL3MBTL1 | |
| SCHEMBL4187978 | 0.77 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CL3MBTL1 | |
| SCHEMBL4177072 | 0.76 | ALDH1A1 (0.68) | PDE4DPDE4APDE4BPDE4CL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069302-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-12 | — | — | US | claimed |
| US-20090069302-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069302-A1 | CHEMICAL COMPOUNDS | TBXA2R, PDE4D, PDE4A | PDE4D 2/4885PDE4A 3/4885PDE4B 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.