Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.35 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.35 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.35 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.35 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.35 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.35 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.35 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 6/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3903334 | 0.79 | CSF1R (0.41) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| Hydrochloric Acid SCHEMBL4192143 | 0.79 | CSF1R (0.39) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL4198391 | 0.79 | CSF1R (0.37) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL5651455 | 0.79 | CSF1R (0.60) | CSF1RKITJAK2SORT1 | |
| Hydrochloric Acid SCHEMBL4186623 | 0.77 | CSF1R (0.45) | CSF1RKIT | |
| SCHEMBL4193241 | 0.73 | CSF1R (0.55) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL3087471 | 0.73 | CSF1R (0.51) | CSF1RPLA2G10PLA2G2AKIT | |
| SCHEMBL15418533 | 0.73 | CSF1R (0.43) | CSF1RKIT | |
| SCHEMBL4189352 | 0.72 | CSF1R (0.35) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL4181729 | 0.72 | CSF1R (0.54) | CSF1RPLA2G10PLA2G2AKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021329-A1 | INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124318-A1 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |