Sugi Predict

Sugi Predict / Compounds / SCHEMBL4193241

SCHEMBL4193241

SCHEMBL4193241

COC[C@H](O)Cc1ccc(C(N)=O)c(C2=CCC(C)(C)CC2)c1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 13/20 0.55
▸ KIT P10721 3/20 0.35
▸ PLA2G10 O15496 5/20 0.33
▸ PLA2G2A P14555 5/20 0.33
▸ PLA2G1B P04054 1/20 0.33
▸ PLA2G5 P39877 1/20 0.33
▸ PLA2G2C Q5R387 1/20 0.33
▸ PLA2G12B Q9BX93 1/20 0.33
▸ PLA2G12A Q9BZM1 1/20 0.33
▸ PLA2G2F Q9BZM2 1/20 0.33
▸ PLA2G3 Q9NZ20 1/20 0.33
▸ PLA2G2E Q9NZK7 1/20 0.33
▸ PLA2G2D Q9UNK4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5654218 0.86 CSF1R (0.55) CSF1RKIT
SCHEMBL3903334 0.86 CSF1R (0.41) CSF1RKITPLA2G10PLA2G2APLA2G1B
Hydrochloric Acid SCHEMBL4186623 0.84 CSF1R (0.45) CSF1RKIT
SCHEMBL3087471 0.79 CSF1R (0.51) CSF1RKITPLA2G10PLA2G2A
SCHEMBL4181729 0.78 CSF1R (0.54) CSF1RKITPLA2G10PLA2G2A
Hydrochloric Acid SCHEMBL4192143 0.78 CSF1R (0.39) CSF1RKITPLA2G10PLA2G2APLA2G1B
SCHEMBL4189352 0.77 CSF1R (0.35) CSF1RKITPLA2G10PLA2G2APLA2G1B
SCHEMBL3089868 0.76 CSF1R (0.50) CSF1RKIT
SCHEMBL3090219 0.76 CSF1R (0.55) CSF1RKIT
SCHEMBL4198391 0.76 CSF1R (0.37) CSF1RKITPLA2G10PLA2G2APLA2G1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9452996-B2 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2016-09-27 — — US disclosed
EP-2021329-B1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2016-04-13 — — EP disclosed
US-20160046602-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2016-02-18 — — US disclosed
US-9221797-B2 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2015-12-29 — — US disclosed
US-8674100-B2 Inhibitors of C-FMS kinase JANSSEN PHARMACEUTICA, N.V. (BE) 2014-03-18 — — US disclosed
EP-2687516-A1 Inhibitors of C-FMS Kinase Janssen Pharmaceutica N.V. (BE) 2014-01-22 — — EP disclosed
EP-2021329-A1 INHIBITORS OF C-FMS KINASE Janssen Pharmaceutica, N.V. (BE) 2009-02-11 — — EP disclosed
WO-2007124318-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-01 — — WO disclosed
US-20070249649-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA, N.V. (BE) 2007-10-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249649-A1 INHIBITORS OF C-FMS KINASE FES, MUSK, FRK CSF1R 58/4885KIT 114/4885PLA2G10 3919/4885
US-20160046602-A1 INHIBITORS OF C-FMS KINASE FES, MUSK, FRK CSF1R 58/4885KIT 114/4885PLA2G10 3919/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.