Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28937519 | 0.83 | ALDH1A1 (0.45) | PARP10ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3353599 | 0.83 | KDM4E (0.55) | PARP10MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4735612 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL364447 | 0.79 | TSHR (0.53) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL10354803 | 0.78 | ALDH1A1 (0.58) | PARP10ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL5388555 | 0.78 | ALDH1A1 (0.75) | PARP10ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2452570 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL5682890 | 0.78 | KMT2A (0.45) | PARP10ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL17530464 | 0.78 | ALDH1A1 (0.59) | PARP10ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3680999 | 0.78 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |