Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.79 |
| ▸ | ERBB4 | Q15303 | 11/20 | 0.75 |
| ▸ | JAK3 | P52333 | 4/20 | 0.75 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.62 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | STK17B | O94768 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | YES1 | P07947 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4344439 | 0.98 | EGFR (0.78) | EGFRERBB2ERBB4JAK3KIT | |
| SCHEMBL4185100 | 0.91 | EGFR (0.68) | EGFRERBB2ERBB4JAK3KIT | |
| SCHEMBL4187414 | 0.89 | EGFR (0.68) | EGFRERBB2ERBB4JAK3KIT | |
| SCHEMBL7245792 | 0.88 | EGFR (0.64) | EGFRERBB2ERBB4JAK3KIT | |
| SCHEMBL4193341 | 0.86 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL4187517 | 0.85 | EGFR (0.85) | EGFRERBB2ERBB4JAK3KIT | |
| SCHEMBL4194333 | 0.84 | EGFR (0.72) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7240170 | 0.84 | EGFR (0.60) | EGFRERBB2ERBB4JAK3KIT | |
| SCHEMBL4195830 | 0.84 | EGFR (0.77) | EGFRERBB2 | |
| SCHEMBL7244420 | 0.84 | EGFR (0.63) | EGFRERBB2ERBB4JAK3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-B2 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2009-11-18 | — | — | EP | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | claimed |
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |