Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4195830 | 0.98 | EGFR (0.77) | EGFRERBB2 | |
| SCHEMBL4194478 | 0.91 | EGFR (0.73) | EGFRERBB2 | |
| SCHEMBL4187480 | 0.88 | EGFR (0.72) | EGFRERBB2 | |
| SCHEMBL4182379 | 0.86 | EGFR (0.79) | EGFRERBB2 | |
| SCHEMBL7245792 | 0.86 | EGFR (0.64) | EGFRERBB2 | |
| SCHEMBL7244420 | 0.84 | EGFR (0.63) | EGFRERBB2 | |
| SCHEMBL4344439 | 0.84 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL4191758 | 0.84 | EGFR (0.75) | EGFRERBB2 | |
| SCHEMBL4187737 | 0.84 | EGFR (0.74) | EGFRERBB2 | |
| SCHEMBL7235000 | 0.83 | EGFR (0.56) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892789-B2 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2009-11-18 | — | — | EP | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | claimed |
| EP-0892789-B1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER LAMBERT CO (US) | 2002-02-27 | — | — | EP | claimed |
| US-6602863-B1 | Irreversible inhibitors of tyrosine kinases | WARNER-LAMBERT COMPANY | 2003-08-05 | — | — | US | disclosed |