SCHEMBL4183156

SCHEMBL4183156

N#Cc1ccc(Oc2ccccc2F)c(Cl)c1

nearest known ligand 0.68

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
AR P10275 5/20 0.68
SLC6A3 Q01959 3/20 0.47
SLC6A4 P31645 3/20 0.47
KCNH2 Q12809 2/20 0.47
SLC22A12 Q96S37 1/20 0.45
SLC6A2 P23975 3/20 0.43
MRGPRX4 Q96LA9 2/20 0.40
CYP11B1 P15538 1/20 0.40
EGFR P00533 1/20 0.40
ERBB2 P04626 1/20 0.40
ERBB3 P21860 1/20 0.40
ERBB4 Q15303 1/20 0.40
ESRRA P11474 1/20 0.40
FFAR1 O14842 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5502088 0.88 AR (0.59) ARSLC6A3SLC6A4KCNH2SLC22A12
SCHEMBL4188121 0.88 AR (0.60) ARSLC6A3SLC6A4KCNH2SLC22A12
SCHEMBL13890526 0.84 AR (0.49) ARSLC6A3SLC6A4KCNH2SLC6A2
SCHEMBL4188051 0.84 AR (0.56) ARSLC6A3SLC6A4KCNH2SLC22A12
SCHEMBL4183157 0.81 AR (0.73) ARSLC6A3SLC6A4KCNH2SLC22A12
SCHEMBL4168825 0.81 AR (1.00) ARSLC6A3SLC6A4KCNH2SLC6A2
SCHEMBL5503503 0.81 AR (0.56) ARSLC6A3SLC6A4KCNH2SLC22A12
SCHEMBL4179470 0.81 AR (0.63) ARSLC6A3SLC6A4KCNH2SLC22A12
SCHEMBL4168094 0.80 AR (0.56) ARSLC6A3SLC6A4KCNH2SLC22A12
SCHEMBL4374224 0.79 AR (0.57) ARSLC6A3SLC6A4KCNH2SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090105349-A1 ANDROGEN MODULATORS WARNER-LAMBERT COMPANY LLC (US) 2009-04-23 US claimed
US-20090105349-A1 ANDROGEN MODULATORS WARNER-LAMBERT COMPANY LLC (US) 2009-04-23 US disclosed
US-20090105349-A1 ANDROGEN MODULATORS WARNER-LAMBERT COMPANY LLC (US) 2009-04-23 US disclosed
EP-1781280-A2 ANDROGEN MODULATORS Warner-Lambert Company LLC (US) 2007-05-09 EP disclosed
WO-2006018723-A2 ANDROGEN MODULATORS WARNER-LAMBERT COMPANY LLC (US) 2006-02-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090105349-A1 ANDROGEN MODULATORS AR, NR5A1, SHBG AR 1/4885SLC6A3 3395/4885SLC6A4 1384/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.