Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 5/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.36 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.36 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.36 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.36 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.36 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.36 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189535 | 0.86 | PLA2G10 (0.38) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL4187849 | 0.85 | ACACB (0.41) | ACACB | |
| SCHEMBL3909606 | 0.83 | PLA2G10 (0.41) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL3902640 | 0.80 | PLA2G10 (0.41) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL4180365 | 0.80 | ALDH1A1 (0.36) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL3903567 | 0.78 | GRM2 (0.39) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL4187992 | 0.78 | GRM2 (0.39) | CSF1RPLA2G10PLA2G2APLA2G1BPLA2G5 | |
| SCHEMBL4184235 | 0.76 | CSF1R (0.54) | CSF1RPLA2G10PLA2G2AGRM2PSMB5 | |
| SCHEMBL4187309 | 0.76 | CSF1R (0.51) | CSF1RPLA2G10PLA2G2AGRM2PSMB5 | |
| SCHEMBL3904818 | 0.75 | PSMB5 (0.39) | CSF1RSCN9AGRM2PTGS2PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021329-A1 | INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124318-A1 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |