Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2749868 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL10647365 | 0.84 | KDM4E (0.48) | HTTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2497122 | 0.82 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10PARP1 | |
| SCHEMBL30666151 | 0.82 | PARP1 (0.51) | HTTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL62707 | 0.80 | PARP1 (0.50) | HTTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL732196 | 0.80 | PARP1 (0.50) | HTTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL28251116 | 0.79 | KDM4E (0.47) | HTTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4601500 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10PARP1 | |
| SCHEMBL1116736 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10PARP1 | |
| Hydrochloric Acid SCHEMBL30786354 | 0.79 | PARP1 (0.49) | HTTKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084470-B2 | Substituted nicotinamide compounds and uses thereof | GRUENENTHAL GMBH (DE) | 2011-12-27 | — | — | US | disclosed |
| US-20090076086-A1 | SUBSTITUTED NICOTINAMIDE COMPOUNDS AND USES THEREOF | GRUENENTHAL GMBH (DE) | 2009-03-19 | — | — | US | disclosed |
| EP-0292990-A1 | 4-Halopyridine-3-carboxamide compounds and herbicidal composition thereof | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1988-11-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076086-A1 | SUBSTITUTED NICOTINAMIDE COMPOUNDS AND USES THEREOF | NNT, NAMPT, NADK | HTT 1584/4885KDM4E 2156/4885ALDH1A1 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.