Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30786354 | 0.98 | PARP1 (0.49) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30666151 | 0.87 | PARP1 (0.51) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL732196 | 0.86 | PARP1 (0.50) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL497429 | 0.85 | PARP1 (0.53) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2497122 | 0.84 | KDM4E (0.56) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9858538 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9339087 | 0.83 | PARP1 (0.47) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL24135774 | 0.82 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL1937751 | 0.81 | PARP1 (0.53) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5196284 | 0.81 | PARP1 (0.53) | PARP1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116813540-A | Refining method of nicorandil intermediate | 上海旭东海普药业有限公司 | 2023-09-29 | — | — | CN | claimed |
| CN-113912617-A | Substituted tricycles and methods of use | 艾伯维公司 | 2022-01-11 | — | — | CN | claimed |
| CN-103370301-B | Process for the manufacture of nicorandil | PROCOS SPA | 2015-03-18 | — | — | CN | claimed |
| CN-103370301-A | Process for the manufacture of nicorandil | PROCOS SPA | 2013-10-23 | — | — | CN | claimed |
| US-20090258887-A1 | Novel Carboxylic Acid Derivatives | DSM ASSETS B.V. (NL) | 2009-10-15 | — | — | US | claimed |
| CN-101268039-A | Novel carboxylic acid derivatives | DSM IP ASSETS BV (NL) | 2008-09-17 | — | — | CN | claimed |
| EP-1926703-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES | DSM IP Assets B.V. (NL) | 2008-06-04 | — | — | EP | claimed |
| WO-2007039059-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2007-04-12 | — | — | WO | claimed |
| CN-116813540-B | Nicorandil middle method for refining intermediate | 上海旭东海普药业有限公司 | 2026-05-01 | — | — | CN | disclosed |
| CN-118130647-A | HPLC analysis method of nicorandil for injection | 成都地奥九泓制药厂 | 2024-06-04 | — | — | CN | disclosed |
| CN-117752618-A | Sterile pharmaceutical composition for treating heart failure and angina pectoris and preparation method thereof | 西安丽彩医药研发有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-114920691-B | Preparation method of N- (2-hydroxyethyl) nicotinamide and preparation method of nicorandil | 海口天行健药物研究有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-115300465-B | Nicotil freeze-dried powder injection for injection and preparation method thereof | 上海旭东海普药业有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116813540-A | Refining method of nicorandil intermediate | 上海旭东海普药业有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-101268039-A | Novel carboxylic acid derivatives | DSM IP ASSETS BV (NL) | 2008-09-17 | — | — | CN | disclosed |
| EP-1926703-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES | DSM IP Assets B.V. (NL) | 2008-06-04 | — | — | EP | disclosed |
| CN-101133019-A | Derivatives of aminobutyric acid inhibiting CPT | SIGMA TAU IND FARMACEUTI (IT) | 2008-02-27 | — | — | CN | disclosed |
| WO-2007039059-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2007-04-12 | — | — | WO | disclosed |
| EP-1080081-A1 | BENZOFUROXAN DERIVATIVES AND THEIR USE IN TREATING ANGINA PECTORIS | Torrent Pharmaceuticals Ltd (IN) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061430-A1 | BENZOFUROXAN DERIVATIVES AND THEIR USE IN TREATING ANGINA PECTORIS | SANKARANARAYANAN ALANGUDI (IN) | 1999-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258887-A1 | Novel Carboxylic Acid Derivatives | AADAC, ALDH7A1, DDC | PARP1 4321/4885KDM4E 2266/4885ALDH1A1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.