Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nicardipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 5/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | THPO | P40225 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nicardipine SCHEMBL41846 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL29465066 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL1653198 | 1.00 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL4309711 | 0.99 | CYP1A2 (0.98) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL4309716 | 0.99 | CYP1A2 (0.98) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34278 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL31059901 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34277 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34279 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL29430153 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4083 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12440482-B2 | 1,4-dihydropyridine compositions, methods of making and use | AMERICAN REGENT, INC. (US) | 2025-10-14 | — | — | US | claimed |
| US-20250268875-A1 | STABILIZED PHARMACEUTICAL COMPOSITION OF 1,4-DIHYDROPYRIDINES WITH HYDROGEN ATOM TRANSFER (HAT) ANTIOXIDANTS | MAIVA PHARMA PRIVATE LIMITED (IN) | 2025-08-28 | — | — | US | claimed |
| US-12383622-B2 | Pre-mixed, ready-to-use pharmaceutical compositions | CHIESI USA, INC. (US) | 2025-08-12 | — | — | US | claimed |
| CN-120053364-A | Preparation process of nicardipine hydrochloride injection | 湖南宝东制药集团有限公司 | 2025-05-30 | — | — | CN | claimed |
| US-20250144030-A1 | OSMOTIC PUMP CONTROLLED-RELEASE TABLET OF INSOLUBLE DRUG AND PREPARATION METHOD THEREFOR | BEIJING WEHAND-BIO PHARMACEUTICAL CO., LTD (CN) | 2025-05-08 | — | — | US | claimed |
| CN-119757553-A | Method for measuring content of benzyl chloride and benzaldehyde in nicardipine hydrochloride by utilizing HPLC | 江苏慈星药业有限公司 | 2025-04-04 | — | — | CN | claimed |
| CN-119613324-A | Preparation method of nicardipine hydrochloride | 广州市桐晖药业有限公司 | 2025-03-14 | — | — | CN | claimed |
| CN-119492814-A | Method for detecting nicardipine hydrochloride related substances | 华仁医学研究(安徽)有限公司 | 2025-02-21 | — | — | CN | claimed |
| CN-119125093-A | Method for constructing aggregation-induced emission multi-residue sensing system based on bionic AR-DBD/LBD | 扬州大学 | 2024-12-13 | — | — | CN | claimed |
| CN-118930478-A | Preparation method of nicardipine hydrochloride | 江苏慧聚药业股份有限公司 | 2024-11-12 | — | — | CN | claimed |
| US-4637930-A | VASODILATION, HYPOTENSIVES | YAMANOUCHI PHARMACEUTICAL CO, LTD. (JP) | 1987-01-20 | — | — | US | claimed |
| EP-0188311-A2 | Pharmaceutical formulation of nicardipine and 1,2-dioxy-omega-trialkylammonium compounds | SYNTEX (U.S.A.) INC. (US) | 1986-07-23 | — | — | EP | claimed |
| US-4565823-A | NICARDIPINE, ANTILIPEMIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-01-21 | — | — | US | claimed |
| EP-0162705-A2 | Injection of nicardipine hydrochloride and production thereof | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1985-11-27 | — | — | EP | claimed |
| US-4555398-A | THERMOSETTING OR THERMOPLASTIC RESIN MOLD | CHISSO CORPORATION (JP) | 1985-11-26 | — | — | US | claimed |
| EP-0153200-A2 | Medicinal patch | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1985-08-28 | — | — | EP | claimed |
| EP-0152281-A2 | Transdermal formulation of nicardipine hydrochloride | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1985-08-21 | — | — | EP | claimed |
| EP-0149475-A2 | Medicaments for the treatment and prevention of liver damage | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1985-07-24 | — | — | EP | claimed |
| EP-0131228-A2 | Nicardipine hydrochloride or nifedipine ointments | YAMANOUCHI PHARMACEUTICAL (JP) | 1985-01-16 | — | — | EP | claimed |
| US-4343789-A | NICARDIPINE AND POLYOXYETHYLENE GLYCOL | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1982-08-10 | — | — | US | claimed |