Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nicardipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.98 |
| ▸ | MAPT | P10636 | 5/20 | 0.98 |
| ▸ | LMNA | P02545 | 4/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.98 |
| ▸ | MEN1 | O00255 | 4/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.98 |
| ▸ | TSHR | P16473 | 3/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.98 |
| ▸ | THPO | P40225 | 2/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.98 |
| ▸ | GMNN | O75496 | 1/20 | 0.98 |
| ▸ | TP53 | P04637 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nicardipine SCHEMBL4309711 | 1.00 | CYP1A2 (0.98) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL1653198 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL41845 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL41846 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL29465066 | 0.99 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34279 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL31059901 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34277 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL34278 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| Nicardipine SCHEMBL29430153 | 0.98 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133180-A1 | NICARDIPINE HYDROCHLORIDE DIHYDRATE AND CHLOROFORMATE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (75%) (ES) | 2009-11-05 | — | — | WO | claimed |
| CN-117567358-A | Nicardipine hydrochloride ethyl semiacetate compound crystal and preparation method and application thereof | 成都地奥九泓制药厂 | 2024-02-20 | — | — | CN | disclosed |
| WO-2009133180-A1 | NICARDIPINE HYDROCHLORIDE DIHYDRATE AND CHLOROFORMATE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (75%) (ES) | 2009-11-05 | — | — | WO | disclosed |