Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL28248131 | 0.98 | CYP3A4 (0.62) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL21380519 | 0.97 | LMNA (0.60) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28115454 | 0.95 | CYP3A4 (0.59) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL16684873 | 0.95 | LMNA (0.57) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29173938 | 0.93 | CYP3A4 (0.56) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL29179928 | 0.91 | CYP3A4 (0.54) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL28975656 | 0.87 | CYP3A4 (0.68) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL23044725 | 0.85 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Succinic Acid SCHEMBL28127025 | 0.85 | CYP3A4 (0.65) | CYP3A4SLC5A7LMNAMEN1KMT2A | |
| Choline SCHEMBL22645159 | 0.84 | CYP3A4 (0.72) | CYP3A4SLC5A7LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118126214-A | Method for curing UV-LED by capsanthin/iodonium salt photoinitiation system | 南京林业大学 | 2024-06-04 | — | — | CN | claimed |
| CN-114921813-B | Electro-deposited zinc ingot processing technology based on weak acid environment leaching | 中宁县宁华再生资源循环利用科技有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-117845058-A | Method for recycling indium and tin from ITO waste target | 云南大学 | 2024-04-09 | — | — | CN | claimed |
| CN-117737449-A | Method for preparing metallic zinc by selectively leaching zinc calcine of zinc sulfide concentrate by using eutectic solvent | 东北大学 | 2024-03-22 | — | — | CN | claimed |
| CN-117737802-A | Bright ruthenium plating electroplating solution, preparation method and application | 东北大学 | 2024-03-22 | — | — | CN | claimed |
| CN-116371195-A | Composite nanofiltration membrane and preparation method and application thereof | 中国科学院过程工程研究所 | 2023-07-04 | — | — | CN | claimed |
| CN-112808305-B | Catalytic system for catalyzing olefin isomerization reaction and application thereof | 山东新和成药业有限公司 | 2022-12-16 | — | — | CN | claimed |
| CN-114921813-A | Electrodeposition zinc ingot processing technology based on weak acid environment leaching | 中宁县宁华再生资源循环利用科技有限公司 | 2022-08-19 | — | — | CN | claimed |
| CN-114854474-A | Low-friction-coefficient anti-wear hydraulic oil | 镇江四联机电科技有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-114702537-A | Method for separating geniposide and aucubin | 中国农业科学院麻类研究所 | 2022-07-05 | — | — | CN | claimed |
| CN-113046109-A | Preparation method and application of low-sulfur low-nitrogen environment-friendly asphalt | 山西中科化美科技有限责任公司 | 2021-06-29 | — | — | CN | claimed |
| CN-113046023-A | Preparation method and application of environment-friendly asphalt | 山西中科化美科技有限责任公司 | 2021-06-29 | — | — | CN | claimed |
| CN-112808305-A | Catalytic system for catalyzing olefin isomerization reaction and application thereof | 山东新和成药业有限公司 | 2021-05-18 | — | — | CN | claimed |
| CN-112522516-A | High-efficiency and environment-friendly recovery method of noble metal palladium in retired solid oxide fuel cell | 武汉理工大学 | 2021-03-19 | — | — | CN | claimed |
| CN-106749805-B | A kind of atom transfer radical polymerization method acted on using low temperature eutectic | 华中科技大学 | 2019-07-09 | — | — | CN | claimed |
| CN-108949658-A | A kind of whole-cell catalyst and its preparation method and application increasing permeability | 江苏科技大学 | 2018-12-07 | — | — | CN | claimed |
| CN-108642520-A | A method of zinc is generated based on choline chloride-malonic acid eutectic system | 南京信息工程大学 | 2018-10-12 | — | — | CN | claimed |
| CN-108048421-A | The method that transfructosylase catalytic efficiency and stability are improved using choline eutectic solvent | 天津科技大学 | 2018-05-18 | — | — | CN | claimed |
| CN-105274598-B | The preparation method of electro-deposition room temperature n-type BiTeSe thermoelectric films in ionic liquid | 天津农学院 | 2017-08-11 | — | — | CN | claimed |
| CN-106518618-A | Method for continuously extracting, rectificating and separating isopropanol-isopropyl ether azeotrope by mixed solvent | 济南大学 | 2017-03-22 | — | — | CN | claimed |