Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584155 | 0.82 | RAB9A (0.60) | KMT2AMEN1L3MBTL1MAPTKDM4E | |
| SCHEMBL3583248 | 0.81 | RAB9A (0.61) | KMT2AMEN1MAPTKDM4EPOLB | |
| SCHEMBL3583065 | 0.79 | MAPT (0.60) | KMT2AMEN1L3MBTL1MAPTKDM4E | |
| SCHEMBL3588056 | 0.78 | NPC1 (0.63) | KMT2AMEN1L3MBTL1MAPTKDM4E | |
| SCHEMBL3585022 | 0.77 | RAB9A (0.67) | KMT2AMEN1L3MBTL1MAPTKDM4E | |
| SCHEMBL28475354 | 0.74 | RAB9A (0.72) | KMT2AMEN1L3MBTL1MAPTKDM4E | |
| SCHEMBL4915021 | 0.74 | NPC1 (0.63) | KMT2AMEN1KDM4ELMNAALDH1A1 | |
| SCHEMBL3593667 | 0.73 | SMN1; SMN2 (0.79) | KMT2AMEN1MAPTKDM4EPOLB | |
| SCHEMBL27903465 | 0.72 | KMT2A (0.75) | KMT2AMEN1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL773337 | 0.72 | LCK (0.72) | KMT2AALDH1A1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | claimed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | claimed |