Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 16/20 | 0.46 |
| ▸ | KIT | P10721 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188266 | 0.86 | CSF1R (0.43) | CSF1RKITCYP2C9 | |
| SCHEMBL5653089 | 0.80 | CSF1R (0.68) | CSF1RKITCYP2C9KDM4ETDP1 | |
| SCHEMBL4190738 | 0.76 | CSF1R (0.48) | CSF1RKIT | |
| SCHEMBL5651779 | 0.68 | CSF1R (0.63) | CSF1RKITCYP2C9 | |
| SCHEMBL3082962 | 0.68 | CSF1R (0.57) | CSF1R | |
| SCHEMBL2909875 | 0.67 | KIT (0.52) | CSF1RKITCYP2C9 | |
| SCHEMBL3083546 | 0.67 | CSF1R (0.60) | CSF1RKIT | |
| SCHEMBL2177843 | 0.66 | CSF1R (0.61) | CSF1RKITCYP2C9 | |
| SCHEMBL2176884 | 0.65 | CSF1R (0.61) | CSF1RKITCYP2C9 | |
| SCHEMBL2907600 | 0.65 | CSF1R (0.64) | CSF1RKITCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021329-A1 | INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124318-A1 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |