Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 14/20 | 0.48 |
| ▸ | KIT | P10721 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188266 | 0.83 | CSF1R (0.43) | CSF1RKIT | |
| SCHEMBL4189779 | 0.81 | CSF1R (0.67) | CSF1RKITNTRK1LCKCYP3A4 | |
| SCHEMBL5650146 | 0.80 | CSF1R (0.66) | CSF1RKITCYP3A4 | |
| SCHEMBL2913376 | 0.79 | CSF1R (0.64) | CSF1RKITNTRK1LCKCYP3A4 | |
| SCHEMBL4185481 | 0.76 | CSF1R (0.46) | CSF1RKIT | |
| SCHEMBL3083546 | 0.69 | CSF1R (0.60) | CSF1RKIT | |
| SCHEMBL3086038 | 0.69 | CSF1R (0.63) | CSF1RKITNTRK1LCKCYP3A4 | |
| SCHEMBL5651779 | 0.69 | CSF1R (0.63) | CSF1RKIT | |
| SCHEMBL3082962 | 0.69 | CSF1R (0.57) | CSF1R | |
| SCHEMBL2913128 | 0.69 | CSF1R (0.64) | CSF1RKITNTRK1LCKCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021329-A1 | INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124318-A1 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |