Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.51 |
| ▸ | KDR | P35968 | 10/20 | 0.51 |
| ▸ | FLT3 | P36888 | 9/20 | 0.51 |
| ▸ | FLT4 | P35916 | 8/20 | 0.51 |
| ▸ | CSF1R | P07333 | 7/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719352 | 0.89 | PDGFRB (0.65) | PDGFRBKDRFLT3FLT4CSF1R | |
| SCHEMBL1099153 | 0.84 | PDGFRB (0.59) | PDGFRBKDRFLT3FLT4CSF1R | |
| SCHEMBL4174136 | 0.83 | PDGFRB (0.52) | PDGFRBKDRFLT3FLT4CSF1R | |
| SCHEMBL4669695 | 0.81 | KDR (0.74) | PDGFRBKDRFLT4CSF1RPDGFRA | |
| SCHEMBL4173823 | 0.81 | BRAF (0.62) | PDGFRBKDRFLT3FLT4CSF1R | |
| SCHEMBL4183098 | 0.80 | PDGFRB (0.57) | PDGFRBKDRFLT3FLT4CSF1R | |
| SCHEMBL4178009 | 0.80 | KDR (0.58) | PDGFRBKDRFLT3FLT4CSF1R | |
| SCHEMBL1099936 | 0.79 | KDR (0.54) | PDGFRBKDRFLT4CSF1RPDGFRA | |
| SCHEMBL1099731 | 0.79 | KDR (0.54) | PDGFRBKDRFLT4CSF1RPDGFRA | |
| SCHEMBL4669692 | 0.78 | KDR (0.66) | KDRFLT4PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233950-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
| EP-1994023-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099317-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233950-A1 | QUINAZOLINE DERIVATIVES | NQO2, CCNI, F12 | PDGFRB 2332/4885KDR 2384/4885FLT3 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.