SCHEMBL4185669

SCHEMBL4185669

CNC(=O)c1cc(Oc2ccc(N(C(N)=O)c3cc4ccccc4nc3OC)cc2)ccc1OC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRAF P15056 3/20 0.39
HDAC1 Q13547 3/20 0.39
HDAC3 O15379 2/20 0.39
HDAC4 P56524 2/20 0.39
HDAC7 Q8WUI4 2/20 0.39
HDAC2 Q92769 2/20 0.39
HDAC10 Q969S8 2/20 0.39
HDAC11 Q96DB2 2/20 0.39
HDAC8 Q9BY41 2/20 0.39
HDAC6 Q9UBN7 2/20 0.39
HDAC9 Q9UKV0 2/20 0.39
HDAC5 Q9UQL6 2/20 0.39
AURKA O14965 1/20 0.39
LCK P06239 1/20 0.39
MET P08581 1/20 0.39
KDR P35968 1/20 0.39
TEK Q02763 1/20 0.39
AURKB Q96GD4 1/20 0.39
RAB9A P51151 2/20 0.38
MAPT P10636 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7971280 0.77 BRAF (0.41) BRAFHDAC1HDAC3HDAC4HDAC7
SCHEMBL2328292 0.77 RAF1 (0.49) BRAFHDAC1HDAC3HDAC4HDAC7
SCHEMBL6834975 0.73 PARP10 (0.43) MAPTPOLBGAAKMT2AMEN1
SCHEMBL258010 0.71 BRAF (0.58) BRAFHDAC1HDAC3HDAC4HDAC7
SCHEMBL257948 0.70 MMP13 (0.59) BRAFHDAC1HDAC3HDAC4HDAC7
SCHEMBL15945346 0.70 SMN1; SMN2 (0.50) RAB9AMAPTSMN1; SMN2
SCHEMBL13388590 0.69 KMT2A (0.47) RAB9AMAPTPOLBGAAKMT2A
SCHEMBL2329688 0.66 BRAF (0.52) BRAFMETKDRRAF1
SCHEMBL2705545 0.66 RAF1 (0.62) BRAFAURKALCKMETKDR
SCHEMBL27517610 0.65 NPC1 (0.46) RAB9AMAPTSMN1; SMN2POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4359817-B2 2009-11-11 JP claimed
JP-2004537511-A 2004-12-16 JP claimed
EP-1379507-A1 HETEROARYL UREAS CONTAINING NITROGEN HETERO-ATOMS AS p38 KINASE INHIBITORS Bayer Corporation (US) 2004-01-14 EP claimed
WO-2002085859-A1 HETEROARYL UREAS CONTAINING NITROGEN HETERO-ATOMS AS p38 KINASE INHIBITORS BAYER CORPORATION (US) 2002-10-31 WO claimed