Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.43 |
| ▸ | CBFB | Q13951 | 1/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641615 | 0.78 | MEN1 (0.47) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL14535299 | 0.78 | MEN1 (0.47) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL30944312 | 0.78 | GAA (0.46) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL11191773 | 0.77 | MEN1 (0.46) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL19642170 | 0.76 | ALDH1A1 (0.46) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL25422553 | 0.75 | GAA (0.43) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL10970856 | 0.75 | MEN1 (0.45) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL10901866 | 0.75 | MEN1 (0.45) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL28591108 | 0.75 | MEN1 (0.45) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL28553141 | 0.75 | MEN1 (0.45) | MEN1KMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021316-A1 | INHIBITORS OF POLO-LIKE KINASES | Abbott Laboratories (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007140233-A1 | INHIBITORS OF POLO-LIKE KINASES | ABBOTT LABORATORIES (US) | 2007-12-06 | — | — | WO | disclosed |
| EP-0013007-A1 | Process for the preparation of 4-methyl-2-amino-benzothiazole | LONZA AG (CH) | 1980-07-09 | — | — | EP | disclosed |