Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186725 | 1.00 | CCR2 (0.44) | CCR2DDB1CRBNPSEN1PSEN2 | |
| SCHEMBL2428195 | 0.95 | DDB1 (0.40) | CCR2DDB1CRBNPSEN1PSEN2 | |
| SCHEMBL2428197 | 0.95 | DDB1 (0.40) | CCR2DDB1CRBNPSEN1PSEN2 | |
| SCHEMBL17770853 | 0.88 | CCR2 (0.44) | CCR2DDB1CRBNPSEN1PSEN2 | |
| SCHEMBL12527633 | 0.86 | CCR2 (0.43) | CCR2DDB1CRBNPSEN1PSEN2 | |
| SCHEMBL1059501 | 0.79 | DDB1 (0.35) | DDB1CRBN | |
| SCHEMBL12493964 | 0.77 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12493968 | 0.77 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12493940 | 0.76 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12493939 | 0.76 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029581-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007126871-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-11-08 | — | — | WO | disclosed |