Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KDR | P35968 | 6/20 | 0.61 |
| ▸ | TUBB4A | P04350 | 15/20 | 0.60 |
| ▸ | TUBB | P07437 | 15/20 | 0.60 |
| ▸ | TUBA3C | P0DPH7 | 15/20 | 0.60 |
| ▸ | TUBA1B | P68363 | 15/20 | 0.60 |
| ▸ | TUBA4A | P68366 | 15/20 | 0.60 |
| ▸ | TUBB4B | P68371 | 15/20 | 0.60 |
| ▸ | TUBB3 | Q13509 | 15/20 | 0.60 |
| ▸ | TUBB2A | Q13885 | 15/20 | 0.60 |
| ▸ | TUBB8 | Q3ZCM7 | 15/20 | 0.60 |
| ▸ | TUBA3E | Q6PEY2 | 15/20 | 0.60 |
| ▸ | TUBA1A | Q71U36 | 15/20 | 0.60 |
| ▸ | TUBA1C | Q9BQE3 | 15/20 | 0.60 |
| ▸ | TUBB6 | Q9BUF5 | 15/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178559 | 0.93 | KDM4E (0.65) | KDM4ENPC1GLAGAAMAPT | |
| SCHEMBL13605748 | 0.82 | TUBB4A (0.48) | KDM4ENPC1GLAGAAMAPT | |
| SCHEMBL4174334 | 0.80 | TUBB4A (0.62) | KDM4ENPC1MAPTRAB9AKDR | |
| SCHEMBL4187690 | 0.79 | TUBB4A (0.50) | KDM4ENPC1GLAGAAMAPT | |
| SCHEMBL4180588 | 0.77 | TUBB4A (0.61) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4178999 | 0.77 | KDR (0.79) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4163521 | 0.77 | KDR (1.00) | GAAKDRTUBB4ATUBBTUBA3C | |
| SCHEMBL4174866 | 0.76 | TUBB4A (1.00) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4184439 | 0.76 | KDR (0.81) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4177038 | 0.75 | TUBB4A (0.60) | KDRTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318438-A1 | Heterocyclic compounds and their use as anticancer agents | CHEN XIAOLING | 2009-12-24 | — | — | US | disclosed |
| US-20090318438-A1 | Heterocyclic compounds and their use as anticancer agents | CHEN XIAOLING | 2009-12-24 | — | — | US | disclosed |
| US-20090318438-A1 | Heterocyclic compounds and their use as anticancer agents | CHEN XIAOLING | 2009-12-24 | — | — | US | disclosed |
| US-20090048301-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048301-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090048301-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048301-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS | TP53, MCL1, VHL | KDM4E 2144/4885NPC1 465/4885GLA 390/4885 |
| US-20090318438-A1 | Heterocyclic compounds and their use as anticancer agents | TP53, MCL1, VHL | KDM4E 2144/4885NPC1 465/4885GLA 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.